If you are encountering an error in sycning your BB device to Desktop Manager, and you get the error: “BlackBerry Desktop Manager has encountered a problem and needs to close. We are sorry for the inconvenience,” follow these instructions:
For BlackBerry Desktop Manager
1. Close BlackBerry Desktop Manager. 2. Open Microsoft® Windows® Explorer and delete the “Research In Motion” folder in the following location:
C:\Documents and Settings\<user_name>\Application Data\
[This deletes all your synchronization settings/history, etc. I actually just renamed the Research in Motion folder in case I wanted to get any information in it back.
When you restart Desktop Manager again in the steps below, the “Research in Motion” directory and subdirectories will be re-created.]
3. Open the BlackBerry Desktop Manager again. 4. Select Synchronize 5. On the Synchronize tab, make sure Synchronize Organizer Data is checked. 6. Select the Configuration tab and click Configure Synch. 7. Re-create your sync settings to sync calendar, contacts, tasks, and notes, etc. 9. Click OK to save your changes 10. Return to the Synchronize tab and perform a synchronization by clicking Synchronize Now.
Thanks to Redflea @ BlackBerryForums.com, and BlackBerry.com Knowledge Base article KB10340